Wednesday, December 31, 2008
The Bane of all my Resolutions
Also there are lots of minigames that I don't remember; I am more used to FFVIII or FFX (neither of which have I beaten -- my brother is an absurd backseat gamer and that took much of the fun away from video games), which are much more straightforward. I think I like the small varieties of gameplay, although I have to admit that I am terrible at just about all of them (just like I'm terrible at most video games).
I had all of these really good resolutions planned, too, but I think in the short term I won't even keep a resolution of "Don't spend every waking moment playing FFVII". So I might have to revise those. We shall see.
Friday, December 26, 2008
Paltry
“Don’t touch that!” the shout rang out across the room. “Don’t you dare!”Saw "Frost/Nixon" today. It was really well done, and sparked a conversation about corruption in government and what Nixon did other than Watergate and whether (to simplify horribly) he was just a total slimeball and a crook or an overall decent president who did some really stupid corrupt things at the end of his tenure and got caught. (Diplomacy with China and Russia? Founding the EPA? wha?)
Jacob stared quizzically at his niece and the decorated paper plate in his hand. Most of the glitter had worn off, the bright colors faded. “What?”
“Put it down, now.”
Jacob set it down, still confused. Annie glared up at him. “That is the special-est award I have ever gotten. It is one of a kind. No one can touch it.”
Jacob stared up at the large mass-produced trophies that adorned the shelves, and the paper plate covered in tempera paint, and thought that maybe he understood.
Also had an adventure trying to get a custom calendar made for my mother. Ritz Camera stores appear to have problems employing non-obnoxious people, and also keeping their printers working. Two stores later, we still had not found a place that could print the calendar anytime in the known future. Which was not the result my mother and I expected, or desired. Especially since my father had received an e-mail telling him not that they had gotten his order, but that the calendar was printed and ready for pickup. Which was quite something in our opinions.
Thursday, December 25, 2008
Oblique
“So, what do you do?” he asked, leaning too close for Sarah’s comfort.To a certain extent, my stubborn angry determination has defeated my writer's block. At least, this drabble was quicker than the last one. So that's good. Also, I've started going over November's Novel and will be posting it starting Jan. 1, with posts every week. It would be nice to be regularly posting something longer than 100 words, again.
She coughed lightly. “You’re psychic. Why don’t you tell me?”
He paused; perhaps offended. “Clever.” No such luck. “You work with Janice.” That wasn’t a surprising insight. “So, HR.” He grinned. “Impressed?”
“Forgive me if I’m not,” she said bluntly.
He smirked. “You have a useless degree in Philosophy from Cornell. You work long hours, without thanks. You don’t go out; haven’t since last year. Janice talked you into this and abandoned you, ‘for your own good’.”
He paused; she stared.
“No, Janice did not tell me.”
Christmas was quiet; no one in my family could sleep last night (as in, everyone was awake at 4 AM), so we didn't do too much today. But I did have time to watch four Doctor Who Christmas Specials (all of the new ones, for those who know or care). I have to say, the newest one (The Next Doctor) is probably my favorite; vying with The Christmas Invasion. I would lean towards saying I like the new one better, largely because some of the themes that they've been playing with -- humans almost as clever, and therefore almost as powerful, as the Doctor, for one, and the Doctor's central loneliness, for another -- are done nicely in The Next Doctor and not even touched in The Christmas Invasion. And I like those themes.
Wednesday, December 24, 2008
Christmastime
I'm sitting in the living room; the rest of the family has gone to sleep after watcing Wall-E (to Kevin from Santa), while tomorrow's dinner boils and bubbles away on the stove (I was bored and overambitious -- yes, it is past eleven here). I have at least an hour's worth of cook time left, and not much of anything to do. I cleaned up the living room (all wrapping paper is gone); I even got my brother to help. And now I'm back to my standard state this break: boredom.
I have not been posting largely because I have not felt like I had anything to write; I have been trying to write this break and have not had much success at all (2 pages of beginning to nothing in particular doesn't count). I think the creative deficit is finally hitting me (last night and this afternoon especially), which spurred the decision to cook, certainly. It was something to do, at least, but it didn't really make me feel like I had brought anything new into the world -- except a batch of pasta sauce that is still incomplete and could have been done hours ago if I had done it the way mom always does it instead of adding too much liquid. And a loaf of cornbread which turned out nicely.
It's been forever since I had an idea for a story, basically, and I'm really beginning to feel it. The drabble below is my attempt at forcing myself to re-enter the fray, even if I feel like I'm rusty and out of shape and have run out of any unique ideas. Honestly, I'm not; I'm burned out intelletcually after finals week and out of practice with writing after my Nano-inspired break. I just need to get back into it. Which is, perhaps, easier said than done.
Perhaps that can be a New Year's resolution. That and a few other things, like "Excersize outside of Silks class" and "Ask more questions" (this is my favorite).
On NPR today a TV critic listed his top 10 TV shows of 2008. Making the list was Pushing Daisies (ABC, I hate you for cancelling one of the few good shows on television) and Doctor Horrible (Yes, even though it was not on television -- it was so awesome they bent the rules).
Drabble: Made Up, inspired by the word "Narcissism"
Juliette primped for the mirror. She smiled at it winningly. Her mother called something from downstairs, but she disregarded it, adjusting her hair infinitesimally.On a completely unrelated note, I am glad the Doctor Who Christmas Special shows in the UK tomorrow; this means I might be able to see it sometime in the next century. (Boo to BBC America for showing the last three Christmas Specials here tomorrow, and not the new one!) And you know you've gone into Doctor Who withdrawal when you start dreaming about the Doctor. I was Martha (I was not "his companion", I was specifically Martha). There were plant-people. I woke up before discovering what their intentions were, but the Doctor was not the least bit afraid. Last night was a big night for dreaming; there was also something about Chicago, but much more of that has faded away since waking.
She looked lovely.
Her date was, of course, waiting. She checked her appearance one last time, making sure nothing had gone awry. No, still beautiful. She almost cried at the beauty of her own visage, but she stopped for the sake of her mascara. She stood, carefully, and turned for the steps.
When she got to the front door, he was gone.
“Where is he?”
“It’s been two hours. Did you expect him to wait forever?”
Wednesday, December 17, 2008
I Found My Heart in San Fransisco?
But somewhat more seriously, as I was walking (slowly, slowly) up from aerial class today towards the MUNI stop, breathing in the cold fog and breathing out slightly warmer fog, considering eating the chocolates I had been given for christmas as dinner (they were delicious), I had one of those movie-homecoming moments. You know, the last scene of the movie that goes with the epilog of the heroine having found a home and a new life and going off to change the world? It just felt comfortable and right. Which is pretty awesome, since I didn't really feel at home in Chicago until the end of my second year or something like that. I think, in part, it is related to the fact that I am doing things that force me out into the city more often than I was in Undergraduate, and also because everyone here is super friendly. Like, whoah.
On the other hand, I went to a stretching class today. Trust me when I say it was seriously hard core. No intro to yoga class, this. As in, they nicknamed it contorture. It appealed to a somewhat older audience than the aerial class I usually take, I think, although I am uncertain as to why -- flexibility goes before strength does, at least as far as I knew.
I'm going to start by saying I am not a contortionist. There are people who are bendy, naturally, and there are people who build muscle mass naturally. I am fairly squarely in the latter category, given my gender and age. When I was a gymnast, I hated it when my coaches would push me into stretches, because it hurt. And I was still not as flexible as my little brother, no matter how much my coaches pushed and pulled and stretched. Now I am perhaps a little more flexible than my little brother (he stopped stretching, I didn't), but I have discovered that it still hurts. And, if I thought that the pushing my gymnastics or diving coaches would do was bad, it was mostly because I had never trained with contortionists. Ouch.
Ouch.
Ouch!
The moment when I realized that I simply cannot do this ever again was when I couldn't breathe because the coach was compressing my lungs against a balance beam (pulling my shoulders back), while critiquing me that I should stop holding my breath and just relax (oh right because that is a perfectly natural thing to do when your arms are being torn out of their sockets); "See? When I said that you stretched farther!" he said as I almost passed out. I should have perhaps said the safe word (you know a class is going to be bad when there's a safe word. It was "Papaya") but I would have felt like a wimp, and my stubborn determination in the face of pain in general serves me well (I will not say whether it served me well in that situation or not, I have not decided yet). Also I couldn't really choke anything out (no air, and all) and settled instead for shaking my head madly.
When I do aerial stuff, I feel challenged and pushed but not that I am trying to get my body to do something it absolutely positively was not made to do. This time, I felt like saying "No, I cannot do that, I have organs there."
I was unaware, up until today, that one could stretch so much one felt sore the next day. I'm worried that tomorrow I might not be able to walk. And this class came highly recommended, too!
I'm also wondering if stretching out my pike and not so much my bridge for years in diving has made my arch worse than the rest of me, which is another explanation for why I was thinking "this class is maybe pretty okay even though it hurts like none other, and it would be super useful to get more flexible" until they started stretching out our backs, when it turned into "O God O God I am in pain and I cannot breathe haallllppp!"
As if to make matters worse, a dancer dropped in to the aerial class who would have been a great contortionist. Part of me is really jealous of people who can bend like that, in part because I think that their poses look so much cooler and prettier than the ones I can do. This is only made worse after 1.5 hours spent undergoing huge amounts of pain in order to... not bend that much. I mean, really. Even just being able to do the splits would be nice. On the other hand, she couldn't really do a straddle-up, or climb the silks. And I think I would be much more disappointed if instead of being able to climb to the top of the silks (or ropes or lampposts or trees or what have you) I could, I dunno, put my leg behind my head, or kiss my foot without bending my knees.
Time for a hot shower and sleep. And fingers crossed that I can get out of bed tomorrow! It will be lucky if I can.
Friday, December 12, 2008
Things
2. My PI for my first rotation lives in a redwood forest. She invited the lab to her home for a Christmas party, and we went on a hike to get to her house. Better yet, she has a slackwire in her backyard. For her five year old daughter. A slackwire! Which is, in my opinion, possibly the most awesome thing ever. I climbed on it, but did not feel comfortable letting go of the balance ropes.
3. My cheesecake was a success! It was tasty, but next time I will 1) put more sugar and more lime in (the filling was a bit bland for my tastes), 2) use unsalted butter + salt on the crust for better control, and 3) possibly try the method where you put the spring-form pan in a dish of water to bake, thus making it cook slower.
4. After close contact with a Saint Bernard and the rain, I smelled like a wet dog. The dog was pretty much the sweetest animal ever. I really like Newfoundlands and Saint Bernards, I've decided, even more than I like big Labradors. Their mellowness is nice. I might like them better if I wasn't allergic, however.
5. Watching the fog come in over the redwood-covered mountains is amazing. Absolutely amazing.
Tomorrow is the latke party; I'm about as prepared as I want to be at this point (cookie dough in the fridge, etc). I just have to hope I don't burn the potatoes. *fingers crossed*
Wednesday, December 10, 2008
Excitement!
She feared becoming the teacher from Charlie Brown – standing in the front of the room, pontificating, while all anyone could hear was “wah wah wah”. She could envision her students’ eyes glazing over, the boy in the back of the room falling asleep, the two girls in the corner passing notes.I have many reasons to celebrate today. First (and most important): I am done with my first quarter of graduate school! W00! I finished up my last final today, hand it in tomorrow at 10 AM, and so that leaves me with a week or so more time to really dedicate myself to my rotation lab before I go on vacation and start my next rotation. This is pretty thrilling to me.
That was, if anyone asked her, why she chose to speak so clearly. Sharp consonants and round vowels would keep her from fading into the ignominy of incomprehensibility.
But she couldn’t explain all that to Johnny when he asked, “Why do you use your teacher’s voice all the time?”
Second: my silks instructor today (I celebrated by going to the city for lessons. This was not an abnormal activity for me, but it was celebratory anyway.) looked at me at the beginning of class and said "You know lots of tricks. You should start trying to tie them together. Your job for today is to make a phrase of two or three tricks." Which was happy (I know lots of tricks!) but terrifying (What do I know about stringing them together?) But I did it, and at the end of class she had everyone (which meant both of my classmates and herself, so not many people) watch while I did my little phrase. It was probably terrible, but I didn't fall down -- I actually came out of the last trick gracefully (which is a big deal for me) and so I was happy with it, especially for the first time. Chris (a classmate) had the same duty, and while his had a lot more cool tricks, he got tired halfway through and it was sloppy afterward. On the other hand, he has a lot of dance experience so he probably has a better idea on where to start with this "choreography" thing.
Saturday, December 06, 2008
Friendliness
They said it was impossible to get past the sentinel; that no one had ever reached the castle unknown. But Daniel had his ways. He was better than the others.Also, my mother laughed at me when I said I was surprised that strangers on the street have conversations with me. She pointed out that I once lent my phone to a (probable) drug dealer on Michigan Avenue. In my defense, I did not think he was a drug dealer, just a man without a phone. (Although it is a good story). She also laughed at my assertion that I was a cynical, east-coast, city-type and not a friendly California type. However, I stand by my assertions and my surprise.
He was not, however, as good as the girl he tripped over in his way through the forest. “Sorry!” she yelped, smiling warmly and moving out of his way. “Are you going to the castle?”
Daniel nodded instinctively. He realized too late that he should be keeping his secrets.
“Marvellous!” she said, cheerily. “I am too!”
“Why?” he asked.
“To tell the king you’re here,” she chirped. “I’m the sentinel.”
Speak of the Devil
It would have been remarkable to run into Brian even if he hadn’t been a subject of conversation at dinner. After all, who expects to run into acquaintances from Chicago when one is in California? But there he was, at the ice cream shop.Yes, this actually happened. I was out with friends tonight, and as such my creative energies were spent being witty. But we did run into another Chicago-ite after talking about him (mostly the fact that he is in Palo Alto) at dinner. Another funny (and ENTIRELY TRUE) story, however:
“Brian!”
“Wow! It’s you again! How’s the quarter been?”
“Alright. Busy. Yourself?”
The conversation was short: two people who don’t really know each other but want to keep up appearances.
“That was cool,” Roger said, as Brian walked away.
“Yeah, but if we had known this would happen, we totally should have talked about Scarlett Johannsen.”
So I was waiting for friends to get frozen yogurt (there is a new trend in Palo Alto, which is sour frozen yogurt with fresh fruit), and this older woman (older than my parents) stands up right behind me. She almost bumps into me, and then suddenly sits back down, so I sort of move out of the way and apologize, assuming that I've gotten in her way somehow. She says that I wasn't in her way and should not be sorry. This sparks a conversation. (Do not ask me how this sparks a conversation, as I do not rightly know.)
She likes my (red wool double breasted) coat, and asks if it is vintage. I say that I made it, and she is impressed, asks me to model it (turn around). She likes the flare (which is my favorite part, so I appreciate that). Asks me what I do, is surprised by "genetics". She is from the midwest, (Michigan, I think) and loves the fact that it doesn't get too cold in Palo Alto over the winter, but admits that icicles and snow in Michigan are beautiful. An older man comes to pick her up, and she asserts that he has had a stroke, and he is totally bonkers, and they aren't married but she has to look out for her fellow students. I am not sure what this meant. As she leaves, she gives me a hug, remarking upon the fact that I am skinny.
I turn back to my friends, who ask "Who was that?" and I have to respond, "I don't know. I've never seen her before in my life." On the one hand, I admit that it is probably odd I have just conversed for five minutes (and hugged?) a woman who I have never met. On the other hand, it seemed the most natural thing to do in the situation. And it's not sketchy if she's a motherly or grandmotherly sort of person. Although it certainly was odd.
Thursday, December 04, 2008
Wallflower
The envelope was fluorescent pink, and still Andy almost discarded it with the rest of his junkmail.
The sender was “The Department of Supernatural Affairs.”
He opened the envelope. An application fell out, and a cover letter.
“Dear Sir,” it proclaimed in big, bold letters,
“You have not come to our attention in a search for applicants for a position at the Department of Supernatural Affairs.
“Are you constantly overlooked? If so, the Department of Supernatural affairs may be perfect for you! Meet other people like you, who use their remarkable unremarkability to be extraordinary and unnoticed.”
Andy blinked. What?
Wednesday, December 03, 2008
Footless
People were rarely surprised that Caty worked with the circus; they were more surprised, however, that she was an acrobat. How could she perform with her… disability?The aerial fabrics class will be offered again next quarter, which is excellent, and I do not think it clashes with any of my classes, which is also excellent. I will keep my fingers crossed!
But she put up with their stares, with their ogling, because once she got on stage everything changed. Suspended, she was as graceful as a prima ballerina standing on the tips of her toes. She floated in silks, and twined with rope; even cold chains lifted her up rather than keeping her down. Freed of gravity, her freakishness was turned to beauty.
After all, who needs feet when they can’t touch the ground?
Bulwark!
“I’m just a simple sailor,” he claimed, glancing warily at his interlocutor. “I have no idea what you are talking about.”In other news, I think I totally freaked out a couple on the MUNI. I was riding home with Chris (from Silks), debating quarter versus semester, and lauding the joys and despairs of a liberal education. The funny thing was that I had forgotten my water bottle, and so had water in a cup without a lid, with which I jogged to the MUNI, spilling water all over my front while Chris held the bus for me. His reaction upon seeing me: "Are you okay?!"
His interlocutor, from the shadows, laughed. “It’s no use hiding anymore,” the gravelly voice came. “I might have believed you once, but now? Your performance on the rigging was not that of a simple sailor.”
“I’ve been at sea all my life.”
“All the other sailors were hiding from the storm; you were climbing like a monkey. And the back flip onto the bulwark? It was a little excessive.”
He winced. The back flip had been his favorite part.
Yes, they stared at us for the rest of the time on the MUNI. I think it helped that the first thing we talked about was dedication, and how it is easier if your friends know you have a strange habit and support it -- this morning, to my "Ugh I only got four hours of sleep last night. Maybe at six I'll take a nap instead of going to the city" the biochemists (Ruth and the Rooses, to be particular) responded instantly "No! You have to do your circus stuff!"
Maybe they just wanted to avoid me, but I'd like to pretend that they had my best interests at heart. And since I learned this really nifty new trick that looks like you're sitting on the silks (without, mind you, tying up your foot), I have them to thank. (It's one of those deceptively easy-looking tricks: where, if someone can do it well, it looks so simple and restful -- you're just sitting there with your legs crossed -- and then you realize that the only reason they're not slipping down the fabrics is because they are pinching it for dear life between their knees.) Also because my roll-down (a trick in which you wrap the fabrics around your waist and roll down them; you control your speed by how fast you feed the fabric through the loop, and you can spin as many times as you want until you hit the ground, but it's easy to lose the silks and get tangled, and body-position is supersuper important and supersuper difficult: it is, in fact, remarkably difficult to hold a hollow position while suspended from your waist, feeling the pinch of fabric and gravity on your lungs, kidneys, liver, etc) is making progress; I can almost sort of do it! w00!
Monday, December 01, 2008
As promised!
The passing of November is the passing of adventure. November is a time when anything is possible, when the sun still shines through the crystalline winter cold. In November, there is still time for this year to surpass all others, still time for one more frantic burst of energy before the long nights and short days of winter curtail our efforts. December is the beginning of the end; December is the bells tolling, slowly, counting down the days, hours, minutes, seconds until the New Year: another year gone, and where are we now?In other news, we discussed the Immortal Strand Hypothesis in journal club today. It postulates that stem cells retain older copies of DNA in their cells, thus preventing or at least reducing the risks of DNA lesions and mutations. Which implies, in turn, that sister chromatids segregate non-randomly. Which is pretty cool, and pretty weird, at the same time. I might edit this post later tonight to explain, if that isn't clear. (One common question is "If each chromatid is made up of one mother and one daughter strand, how can you have newer or older copies?" -- for now, the short answer is: think of the next cell division.)
What have we done that was worthwhile?
Sunday, November 30, 2008
Success!
1) Turned on the pilot light (with help). Now my apartment is toasty warm instead of chilly.
2) Cooked a Turkey breast (without hardly any help!). It turned out absolutely delicious, if I do say so myself -- the breast meat was tender enough that even I (a sworn dark-meat person) loved it. I still have some in my refrigerator. Sammiches? Yes. The rest of Thanksgiving dinner (challah, mashed potatoes, vegetables, apple crisp, gravy) was a riotous success as well. With the possible exception of the gravy, which was... very thick. In my defense, I had not made gravy before, and my father did say "equal parts drippings and flour". But, all in all, I need more excuses to make large meals and bake bread. Also the time to do so.
3) Fixed the light in the kitchen. This was, admittedly, in no part my doing. It was also in no part within my abilities, since it required someone to fix wiring somewhere inside the walls. But the landlord is fixing things in the apartment next to mine, and halfway through making the turkey, the light came on. Thanksgiving miracle!
4) Strung Patio Lights (they are not christmas lights if I leave them up after new year's). They are warm and welcoming.
5) Made a desk (w00!). It is just a shelf built into the wall, but since I hate powertools and this required using a power drill, I am proud of myself nonetheless. After all, I have a battle scar from when a power drill attacked me. The desk is pine, stained bright red, and sitting in the nook in my bedroom. I love it!
6) Finished this year's NaNoWriMo novel! All told, it is 76,440 words long and 156 pages. It is not my worst work, but not my best either, in my opinion. I think it is, however, a good sequel, so I am not ashamed. At least, I will not be ashamed once I have edited it.
7) Investigated another clue for the scavenger hunt. I now have 3 clues written and 4 more planned out. I can stop now, or come up with one more clue. Woo!
Hopefully, now that November is over, I will return to a more regular posting schedule. The plan is to go back to posting a word-of-the-day drabble every day. We'll see about that.
And, to inaugurate my return, a drabble! Inspired by the word "Incursion".
Professor Randolph knew that 150 people were registered for his class, but he also knew that only one quarter of those people ever attended lecture. So he was not prepared for a full classroom on that dreary Monday morning. Unless he was very much mistaken, there were more than two hundred students in the lecture hall.
Frankly, it distressed him.
He cleared his throat. “I don’t mean to be obtuse,” he said, “But you can’t all be registered for this course.”
A rolling laughter swept the audience, but there was no specific reply.
Professor Randolph, baffled, turned to the board.
Sunday, November 23, 2008
Turkey Week
Also, the closer it comes the more I realize that I have no idea what the hell I am doing. It will, potentially, be an exciting Thanksgiving. At least there will only be four other people to witness my crazed humiliation.
Wednesday, November 19, 2008
"Your Spontaneity is Delicious"
I guess what this means is that I am an extrovert. (Gasp; who would have thought? Although I must admit that I did not think I was an extrovert until fairly recently. Yes, even though I like getting up in front of people and performing, and even though I talk to strangers, and even though I talk to as many people as I can about even the most minor of decisions, and even though I get lonely really really really easily. I can be dense sometimes.)
Point being that at 7:00 tonight I was feeling next to dead, from want of sleep and sociality and who knew what else. And so I dragged myself to a coffee shop, where I had the (good?) fortune to happen upon a monologue slam (like a poetry slam, only with dramatic monologues, which, fortunately, I am not quite as bad at writing). One of the performers sat next to me; I complimented her on her performance (it was quite good), and she said I should write something. I only had five minutes to go, and had not thought of anything in particular, so I frowned and told her as much.
A minute later, I had an idea.
Four minutes later, I had half a monologue, which I performed. I could tell that everyone wanted it to go on, to reach a conclusion, and was shocked when it didn't -- when I stopped halfway through a thought. But I wasn't going to improvise. And for the roughly ninety seconds when I was reading in front of them, pretending not to be a geneticist but rather to be an uncertain undergraduate once more, dallying and dabbling in all sorts of things while I still could, and when people cheered when I said I was from Chicago, and when people laughed at my attempts at humor, I was outside of myself, and it was wonderful.
For a moment, I wasn't an awkward first year genetics graduate student desperately trying to make friends and get a program to work correctly for once so that she could have made some progress, somewhere, sometime, in her rotation project. I wasn't even, as one of the other first year genetics students said, "[practically] a biochemist", due to the fact that I was practically ostracized from my own department socially simply because of my outspoken, extraverted (okay, I said it) personality. (According to him, all the biochemists are the same person, with the possible exception of Ruth, who is "quiet". Ruth objects to this, saying that she is gregarious and sociable and extraverted and just doesn't talk in class -- which is probably true, but even if she is outspoken compared to the geneticists, the biochemists make her seem shy and retiring -- and Alex objects to this as well, saying that he is different because he mumbles -- which is a less compelling argument.) Instead, I was special, because I could go up in front of people and read two hundred words that I had just written about who-knew-what (I believe it was winter, and the fact that I keep expecting it to come and it never does), two hundred words that I knew could be better or cleaner or wittier if I could sit down and edit them carefully and consider each of them, two hundred words that I hadn't had time to think about how I would deliver or even learn to the point that I could read them without looking mostly at the page, read two hundred words of a rough draft of an essay I will never write and have it be fun, have it be exciting, have it be goofy and exhilirating instead of embarrassing and scary. And simultaneously, I was surrounded by people who were more special than I was -- my monologue was not the cleverest nor the best delivered, by any stretch of the imagination -- but were shared by the common bond of, perhaps, "we like doing scary things".
I forgot to tell them my last name; everyone else was "Joe Smith" or "Diane Wang" or even "John Do" (I don't know if that's his real name, I hope it is, because that would be hilariously awesome), and I was just "Elizabeth". But it was okay. No one cared, least of all myself.
And afterward, the performer who I had complemented found me again, and told me "Your spontaneity is delicious," which I took as a huge compliment. I aspire towards brave spontaneity; towards not giving myself time to worry that something will go wrong, towards not always needing a plan and a backup plan and a backup backup plan.
Hopefully, that will have given me the boost I needed; enough energy to push me through the rest of the quarter. Or at least until I can go Christmas Carolling with the Biochemists. (Since I might as well be a biochemist, according to some, and since Krystal has agreed to assist with the carolling endeavor.) Or rather, at least until I can get this scavenger hunt party underway (it is a traditional scavenger hunt (one clue leading to the next leading to the next) in which the prize is fixings for a party, and everyone gets to join in at the end). Which will not be performance-based, but will be tons of fun. I have several ideas that will possibly cause injury and/or hypothermia, unfortunately. So maybe some of them will be postponed until summer, when at least one of those risks will be abnegated.
And, because the Big Game (TM) is on Saturday (might or might not go up to Berkeley for it):
Go Cardinal! Beat Cal!
Saturday, November 15, 2008
Genome versus Epigenome
And, since word count no longer is of primary importance, I can talk about something else. Namely, this past week's New York Times Science Section, which focused on a subject close to my heart: epigenetics. (Epigenetics and fiction, I just need to mention circus stuff in this post and it will be a summary of my life.)
If you haven't read it, you should -- it's a pretty good read and a decent introduction to epigenetics. Here's a summary article.
And here is my caveat, in which I say that I have a bias. I am a geneticist. I study epigenetics. And, reading this article, I felt the need to stand up for the power of the gene, or at least the DNA sequence.
Robert Tjian gave a talk at Stanford two weeks ago. He's the next President of HHMI, and studies how genes are regulated in a cell-specific manner. And he said, something like three times in his talk and in a smaller discussion afterward, that it all comes down to transcription factors, specific cis-acting binding sites, and, effectively, sequence. Sequence is still everything, sequence is dictating the changes, even when the changes result in variable interpretation of sequence. I asked him about epigenetics, in part because anyone who studies cell differentiation in this day and age has to consider epigenetics, and what he said was, I felt, particularly revealing. He didn't deny that methylation marks, histone modifications, nucleosome positioning, and whatever other epigenetic mark you can think of are certainly important in development and in differentiation, especially in producing stably differentiated cells. However, he said, even these marks, eventually, come down to sequence.
Take, for example, something that seems overtly epigenetic. A cell divides, and upon division, whichever daughter cell is closer to an external signal remains a stem cell while the daughter cell that is farther away differentiates. How does this come down to sequence? Well, there are specific genes for specific receptors on the surface of the cell which interact with that external signal and cause a signalling cascade resulting in a set of transcription factors being upregulated to cause the differentiation, for one thing. And there are other specific genes which organize and create the mitotic spindle such that when the cell divides, one of them actually is closer to the external signal than the other. Even what appears to be an epigenetic effect based on the location of the cell relative to other cells is, in the end, controlled by genes. There are protein-coding genes which you can knock out which disrupt many, many parts of this process, and each causes a defect in differentiation.
Likewise, consider "position effects" in eukaryotic molecular cloning. Depending on where a researcher inserts an ectopic sequence into the genome of a eukaryote (for example, yeast, or mammalian cell culture), that same ectopic sequence will be expressed at different levels, perhaps very highly and perhaps not at all. Surely this is proof that, finally, sequence doesn't matter: same sequence, different expression, right? Only it's not the same sequence, if we look at a slightly larger level. Neighboring genomic sequences differentiate one situation from the other, and dropping in large sequence buffers called "insulator elements" to situate the ectopic sequence in a more neutral genomic environment goes a long way toward ameliorating "position effects."
The article I linked from the New York Times says, basically, that since only 1% of sequence codes for protein, 99% of sequence is irrelevant, and hence, sequence is 99% irrelevant. However, I would argue instead that since only 1% of sequence codes for protein, the remaining 99% is where all the really interesting stuff occurs. It still comes down to sequence; we just need to redefine what we mean by sequence.
Tuesday, November 11, 2008
Fortune
But in the spirit of bad chinese take out, my fortune was, probably, the second most oddly specific fortune cookie I have ever seen. (It still doesn't beat "You will see the Great Pyramid in Egypt.")
While the rest of my cohort was opening cookies to reveal pretty standard fortunes (Good luck comes to those who wait, A significant change is just around the corner, Beware Japanese waitress bearing fortune cookies), I cracked open the shell and read "You will attend an unusual party, and meet someone important."
I think there is only one possible explanation: sometime soon, I will be blindfolded, kidnapped, and taken to an underground sumo-wrestling party, where I will meet Joey, a talking Orangutan sumo-wrestling champion who will lead the ape rebellion. Our conversation will mean that when the revolution does comes, I will not be torn to pieces by screaming monkeys.
Not a bad fortune, all said. Probably better than those poor sods who got "A significant change is just around the corner."
ETA: Updated word count (for those of you who care, and those of you who don't): 40,002. I am 4/5 done with my nano goal, and only 1/3 done with the month. Time to sit back, relax, and coast to the finish line. Or spend lunch breaks, evenings, early mornings, and every free moment I have writing because, hey, who wouldn't use an excuse to write a hilariously bad novel when they could be doing useful things?
ETA2: I am sitting outside, and had missed, for quite some time, the large airship flying across the sky above campus. As in, white blimp labeled "Airship Ventures" with a sign painted on its underbelly: a number to call to schedule your own zeppelin ride.
The (steampunk) future is here, for the rich and famous, and apparently it takes place on a zeppelin. Although the airship could have done with some more brass, I feel.
Sunday, November 09, 2008
Verbosity
I think, to be honest, that the kind of writing I have been doing lately does not suit itself to the kind of writing I am comfortable posting on this blog. For the following reason. Most of the fiction I have posted on this blog are drabbles; very short, and hence I have had time to look over every word and carefully choose it as I go. While the longer (full short story) pieces I have posted have definitely improved by being looked at by Ayn, especially, even they were more ready to be looked over than my Nano piece. Nanowrimo is, if anything, the antithesis of how I write drabbles and short stories: in order to make it through the month, I can't edit as I go. I have to just write something and promise myself I'll look throug it and make it better later. That's what January and February are for. I've already told anyone who asks that they can read my novel, at the earliest, in March. (Apparently novel-writing science graduate students are rare enough that my friends are surprised and at least play lip service to wanting to read my work.) That's when it will finally be fit for other people to read. There might be some sections that need less editing than others, but all of it will need to be gone through with a fine-toothed comb before I even come close to posting it in total online.She did not begin to run until she felt the spring sunlight on her face, and smelled last night’s rain in the ground. And when she finally did, after months of a concrete cell with no contact with the outside world, she almost broke down and cried with joy. She ran, she slipped, she skidded, she fled and she flew through the foggy forest surrounding the prison, but even this forest which would have scared the bravest human was home to Nerissa Zephyr. She could taste the sunlight and the dew in the air, and she could sense how desperately they had missed her during her incarceration. She was free, again; free from her cell and more importantly free from the future depicted in the crystal ball. The world was hers, and the arms of Albion and Naid and Corundum stretched to welcome her back.
But nothing, no smell of rain or warmth of sun or feel of earth beneath her feet, nothing compared to the homecoming of finally, once more, after so very long, feeling the breeze against her skin. It enveloped her, caressed her, and she thought for the first time in a long, long time that this was what it meant to be a fairy, and especially, this was what it meant to be Nerissa Zephyr. Not beauty, not grace, not cleverness, not the magic she had used to make herself invisible. To be herself was to be one with the wind, to hear it whisper in her ear, play with her still dingy straw-colored hair, brush against her prison garments, warm her skin and her heart. She thought back to her lessons with Professor Johnson, and her sessions with James, and all the nights making up magic in her cold jail cell, and she frowned in concentration. If she could make herself invisible, then there was no limit to what she could do. She lifted her hands, and made herself lighter than a feather, and the breeze picked her up tenderly, carefully, like a child. And then she spread her arms wide, willing the wind to carry her home.
It did.
And, with that, my nose goes back to the grindstone!
Wednesday, November 05, 2008
I should maybe not be posting this
Prop 8, at the moment, is ahead by something like 4 points, with all precincts reporting and only absentee ballots etc to count. It could still change; but it seems to me that this is, at the very least, more certain than Ohio was at 9 PM Eastern Standard Time last night, and so I am (perhaps prematurely) disappointed. This morning my sentiment (and desire to make sweeping generalizations) could be summarized by "Fuck Los Angeles, San Francisco is the only place in this state that makes any sense." (The SF bay area came out against the proposition, while the LA and San Diego areas and much of rural California came out for it). I've calmed down a little bit, (emphasis on little), although I think that Chicago would be a much happier place to be right now.
My remaining problem with the Yes-on-8 campaign is that, if they win (it's close enough that we need to count absentee ballots), they won on a combination of misinformation and straight-up lies. They made it about protecting children from being taught about homosexuality in schools when existing laws in California ensure that parents would be able to take their children out of any such class. They made it about the freedom to practice religion when no one would force a priest to marry two men if he didn't want to. They spun a fairy-tale of a world in which homosexuality is the norm and someone could be prosecuted (they said this, although I feel like they must mean persecuted) for being adamant that it is a sin. However, in the end, proposition 8 does one thing and one thing only. It eliminates a right for a specific group of people. It isn't protective; it is discriminatory. It isn't about wider issues; it boils down to straight up bigotry and one group of people imposing their beliefs on another group of people.
I hope this doesn't boil down to religion. I really hope it doesn't, because some of the best and brightest people I know are very religious and I do not think they would have voted for prop 8 (in some cases, I know they wouldn't and/or didn't). The only way I see this being about religion is if it is about moral absolutism; religion allows you to say "this is morally wrong" in a victimless crime (such as two men who love each other dearly and have been in a relationship for 21 years getting married). But in general I don't think that it is about religion, and I don't think it is about right and wrong, I think it is about something far more difficult to pin down; something far more subtle. I think that this is about the careful distinction we have to make between "what is wrong" and "what should be illegal". The two are not the same. There are some things which may not be wrong but are illegal (rewarding people for voting, without asking how they voted). There are other things that may be wrong, but should not be illegal (making racist statements, for example, which might not be the best parallel in my opinion because no one is hurt by two people getting married, whereas people are hurt by racist comments).
One last thing that I thought of today, while trying to distract myself from worrying about this by doing experiments. The proponents of prop 8 claim that if it fails, it will usher in a new era in which it will not be acceptable to be religious, and in which kindergardeners will be taught that homosexuality is okay. I, as an atheist pinko commie starbucks-drinking hippie liberal, didn't want to do any of that -- shut down churches, preach to kindergardeners -- until they said I did. But their lies and accusations make me angry enough to turn me into the very villian they make of me. It's something that I have to fight, not to lash out at people who make false accusations, and it's something I consciously do fight, but I feel like those accusations are a self-fulfilling prophecy. Accusing people of being evil and wanting to bring you down is as good a way as any of making people want to bring you down.
My next post will include part of my November's novel.