I am interested in the epigenetic regulation of placentalHaiku: development, in particular the role of DNA methylation. The epigenetic profile of the placenta appears to be more flexible and dynamic than the embryo proper, as evidenced by significantly lower levels of total DNA methylation and striking loss of imprinting at many loci in extraembryonic tissues. However, knockouts or inhibition of the DNA-methylating enzymes (DNMTs) result in malformation of the placenta. I am examining the role of DNMTs in the placenta with tissue-specific knockdowns, and using high throughput sequencing techniques to clarify the extent of loss of imprinting in the placenta.
How cells interpret genomes
Though strictly controll'ed in embryoThe genome seems more flexible outside And where development will progress slow
Environment must always be denied Those marks which seem to regulation tied Are rarer far in afterbirth than son; And in placenta both alleles transcribed Which fetus sees the choice of only
And yet those tissues with controls undone In both the embryo and extra part Are compromised and stunted every one So necessary the controlling mark I study why this freed placenta fails And what its flexibility entails.