Drabble:
I am interested in the epigenetic regulation of placentaldevelopment, in particular the role of DNA methylation. Theepigenetic profile of the placenta appears to be more flexible anddynamic than the embryo proper, as evidenced by significantly lowerlevels of total DNA methylation and striking loss of imprinting atmany loci in extraembryonic tissues. However, knockouts orinhibition of the DNA-methylating enzymes (DNMTs) result inmalformation of the placenta. I am examining the role of DNMTs inthe placenta with tissue-specific knockdowns, and using highthroughput sequencing techniques to clarify the extent of loss ofimprinting in the placenta.Haiku:
Epigenetics:Sonnet:
How cells interpret genomes
And environment
Though strictly controll'ed in embryoThe genome seems more flexible outsideAnd where development will progress slow
Environment must always be deniedThose marks which seem to regulation tiedAre rarer far in afterbirth than son;And in placenta both alleles transcribedWhich fetus sees the choice of only
And yet those tissues with controls undoneIn both the embryo and extra partAre compromised and stunted every oneSo necessary the controlling markI study why this freed placenta failsAnd what its flexibility entails.
1 comment:
Sonnet = AWESOME
You need to submit that somewhere. I don't know what the right venue would be, but I bet there are other people out there who appreciate both genetics and Shakespeare. =D
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